Mar 4, 2026 · 12 min watch
Ozempic For Weight Loss: When It's Worth It (And When It's Not)
GLP-1 drugs mimic a gut hormone that suppresses hunger, slows gastric emptying, and improves glycemic control. A New England Journal of Medicine trial on semaglutide showed average loss of 15% of body weight. The problem is how they are used. Up to 40% of the weight lost can be lean muscle.
Joey lays out the five criteria he requires before a client even discusses this with a doctor, including a BMI of 40 with a serious comorbidity and documented lifestyle attempts. He also covers what almost nobody plans for: an exit strategy of tapering the dose, reverse dieting back to maintenance, and holding training volume.
What You'll Learn
- Up to 40% of GLP-1 weight lost is muscle
- Two thirds of lost weight returns within a year
- Exit plan: taper dose, reverse diet, keep lifting
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